2024

Frasconi, T.M., Kurts, C., Dhana, E., Kaiser, R., Reichelt, M., Lukacs-Kornek, V., Boor, P., Hauser, A.E., Pascual-Reguant, A., Bedoui, S., Turner, J.E., Becker-Gotot, J., and Ludwig-Portugall, I. (2024). Renal IL-23-Dependent Type 3 Innate Lymphoid Cells Link Crystal-induced Intrarenal Inflammasome Activation with Kidney Fibrosis. J Immunol  213, 865-875 10.4049/jimmunol.2400041 [Open Access]

Warmbrunn, M.V., Bahrar, H., de Clercq, N.C., Koopen, A.M., de Groot, P.F., Rutten, J., Joosten, L.A.B., Kootte, R.S., Bouter, K.E.C., Ter Horst, K.W., Hartstra, A.V., Serlie, M.J., Soeters, M.R., van Raalte, D.H., Davids, M., Levin, E., Herrema, H., Riksen, N.P., Netea, M.G., Groen, A.K., and Nieuwdorp, M. (2024). Novel Proteome Targets Marking Insulin Resistance in Metabolic Syndrome. Nutrients  16 10.3390/nu16121822 [Open Access]

Weiss, F.D., Alvarez, Y., Shakeri, F., Sahu, A., Leka, P., Dernst, A., Rollheiser, J., Vasconcelos, M., Geraci, A., Duthie, F., Stahl, R., Lee, H.E., Gellner, A.K., Buness, A., Latz, E., and Meissner, F. (2024). Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in Nlrp3(tm1Flv) mice. Cell Death Differ  10.1038/s41418-024-01379-2

Graelmann, F.J., Gondorf, F., Majlesain, Y., Niemann, B., Klepac, K., Gosejacob, D., Gottschalk, M., Mayer, M., Iriady, I., Hatzfeld, P., Lindenberg, S.K., Wunderling, K., Thiele, C., Abdullah, Z., He, W., Hiller, K., Händler, K., Beyer, M.D., Ulas, T., Pfeifer, A., Esser, C., Weighardt, H., Förster, I., and Reverte-Salisa, L. (2024). Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosis. Mol Metab, 101963 10.1016/j.molmet.2024.101963 [Open Access]

Khani, S., Topel, H., Kardinal, R., Tavanez, A.R., Josephrajan, A., Larsen, B.D.M., Gaudry, M.J., Leyendecker, P., Egedal, N.M., Güller, A.S., Stanic, N., Ruppert, P.M.M., Gaziano, I., Hansmeier, N.R., Schmidt, E., Klemm, P., Vagliano, L.M., Stahl, R., Duthie, F., Krause, J.H., Bici, A., Engelhard, C.A., Gohlke, S., Frommolt, P., Gnad, T., Rada-Iglesias, A., Pradas-Juni, M., Schulz, T.J., Wunderlich, F.T., Pfeifer, A., Bartelt, A., Jastroch, M., Wachten, D.*, and Kornfeld, J.W.* (2024). Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function. Nat Metab 10.1038/s42255-024-01033-8 [Open Access].

Oberkircher, L.M., Scheiding, V.M., Linda Rafeld, H., Hanssen, E., Hansen, J.N., Fleischmann, M.J., Kessler, N., Pitsch, D., Wachten, D., Kastenmüller, W., Brown, A.S., Hartland, E.L., van Driel, I.R., Ng, G.Z., and Garbi, N. (2024). Opposing roles of resident and infiltrating immune cells in the defence against Legionella longbeachae via IL-18R/IFN-γ/ROS axis in mice. Mucosal Immunol  10.1016/j.mucimm.2024.05.001 [Open Access].

Rodrigo, M.B., De Min, A., Jorch, S.K., Martin-Higueras, C., Baumgart, A.K., Goldyn, B., Becker, S., Garbi, N., Lemmermann, N.A., and Kurts, C. (2024). Dual fluorescence reporter mice for Ccl3 transcription, translation, and intercellular communication. J Exp Med  221 10.1084/jem.20231814

Scholz, R., Brösamle, D., Yuan, X., Beyer, M., and Neher, J.J. (2024). Epigenetic control of microglial immune responses. Immunol Rev  323, 209-226 10.1111/imr.13317 [Open Access].

Seep, L., Grein, S., Splichalova, I., Ran, D., Mikhael, M., Hildebrand, S., Lauterbach, M., Hiller, K., Ribeiro, D.J.S., Sieckmann, K., Kardinal, R., Huang, H., Yu, J., Kallabis, S., Behrens, J., Till, A., Peeva, V., Strohmeyer, A., Bruder, J., Blum, T., Soriano-Arroquia, A., Tischer, D., Kuellmer, K., Li, Y., Beyer, M., Gellner, A.-K., Fromme, T., Wackerhage, H., Klingenspor, M., Fenske, W.K., Scheja, L., Meissner, F., Schlitzer, A., Mass, E., Wachten, D., Latz, E., Pfeifer, A., and Hasenauer, J. (2024). From Planning Stage Towards FAIR Data: A Practical Metadatasheet For Biomedical Scientists. Scientific Data  11, 524 10.1038/s41597-024-03349-2 [Open Access].

Kayvanjoo, A.H., Splichalova, I., Bejarano, D.A., Huang, H., Mauel, K., Makdissi, N., Heider, D., Tew, H.M., Balzer, N.R., Greto, E., Osei-Sarpong, C., Baßler, K., Schultze, J.L., Uderhardt, S., Kiermaier, E., Beyer, M., Schlitzer, A., and Mass, E. (2024). Fetal liver macrophages contribute to the hematopoietic stem cell niche by controlling granulopoiesis. Elife  13, e86493 10.7554/eLife.86493 [Open Access].

Theobald, H., Bejarano, D.A., Katzmarski, N., Haub, J., Schulte-Schrepping, J., Yu, J., Bassler, K., Ament, A.L., Osei-Sarpong, C., Piattini, F., Vornholz, L., T'Jonck, W., Györfi, A.H., Hayer, H., Yu, X., Sheoran, S., Al Jawazneh, A., Chakarov, S., Haendler, K., Brown, G.D., Williams, D.L., Bosurgi, L., Distler, J.H.W., Ginhoux, F., Ruland, J., Beyer, M.D., Greter, M., Bain, C.C., Vazquez-Armendariz, A.I., Kopf, M., Schultze, J.L., and Schlitzer, A. (2024). Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation. Nat Immunol  10.1038/s41590-024-01830-z [Open Access].

Weighardt, H., Shapiro, M., Mayer, M., Förster, I., Stockinger, B., and Diny, N.L. (2024). The aryl hydrocarbon receptor (AHR) repressor limits expression of antimicrobial genes but not AHR-dependent genes in intestinal eosinophils. J Leukoc Biol  10.1093/jleuko/qiae105 [Open Access].

Müller, S., Kröger, C., Schultze, J.L., and Aschenbrenner, A.C. (2024). Whole blood stimulation as a tool for studying the human immune system. Eur J Immunol  54, 2350519 https://doi.org/10.1002/eji.202350519 [Open Access].

Müller, L., Nasr, A.R., Jux, B., Makdissi, N., Trowbridge, J.W., Schmidt, S.V., Schultze, J.L., Quast, T., Schulte-Schrepping, J., Kolanus, W., and Mass, E. (2024). Differential impact of high-salt levels in vitro and in vivo on macrophage core functions. Molecular Biology Reports  51, 343 https://doi.org/10.1007/s11033-024-09295-x [Open Access]

Torres, S.V., Man, K., Elmzzahi, T., Malko, D., Chisanga, D., Liao, Y., Prout, M., Abbott, C.A., Tang, A., Wu, J., Becker, M., Mason, T., Haynes, V., Tsui, C., Shakiba, M.H., Hamada, D., Britt, K., Groom, J.R., McColl, S.R., Shi, W., Watt, M.J., Le Gros, G., Pal, B., Beyer, M., Vasanthakumar, A., and Kallies, A. (2024). Two regulatory T cell populations in the visceral adipose tissue shape systemic metabolism. Nature Immunology  25, 496-511 10.1038/s41590-024-01753-9 [Open Access]

Liu, D., Aziz, N. A., Imtiaz, M. A., Pehlivan, G., Breteler, M. M. B. (2024) Associations of measured and genetically predicted leukocyte telomere length with vascular phenotypes: a population-based study. GeroScience, 46 (2), 1947-1970. https://doi.org/10.1007/s11357-023-00914-2 [Open Access]

Fandrey, C. I., Konopka, P., Jentzsch, M., Zackria, A., Maasewerd, S., Latz, E., Schmid-Burgk, J. L. (2024) Cell Type-Agnostic Optical Perturbation Screening Using Nuclear In-Situ Sequencing (NIS-Seq). bioRxiv 2024.01.18.576210. https://doi.org/10.1101/2024.01.18.576210

Sieckmann, K., Winnerling, N., Silva Ribeiro, D. J., Kardinal, R., Steinheuer, L. M., Schermann, G., Klausen, C., Blank-Stein, N., Schulte-Schrepping, J., Osei-Sarpong, C., Becker, M., Bonaguro, L., Beyer, M., Thurley, K., May-Simera, H., Zurkovic, J., Thiele, C., Ruiz de Almodovar, C., Mass, E., Wachten, D. (2024) BBSome-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue. bioRxiv 2024.01.25.576526. https://doi.org/10.1101/2024.01.25.576526‍

Silva Ribeiro, D. J., Yuksel, S., Dolf, A., & Wachten, D. (2024). Isolation and Flow Cytometry Analysis of Macrophages from White Adipose Tissue. Methods Mol Biol, 2713, 149-158. https://doi.org/10.1007/978-1-0716-3437-0_10

2023
Menaker, Y., van den Munckhof, I., Scarpa, A., Placek, K., Brandes-Leibovitz, R., Glantzspiegel, Y., Joosten, L.A.B., Rutten, J.H.W., Netea, M.G., Gat-Viks, I., and Riksen, N.P. (2023). Stratification of Atherosclerosis based on Plasma Metabolic States. J Clin Endocrinol Metab  10.1210/clinem/dgad672 [Open Access]

Bassler, K., Schmidleithner, L., Shakiba, M. H., Elmzzahi, T., Kohne, M., Floess, S., Scholz, R., Ohkura, N., Sadlon, T., Klee, K., Neubauer, A., Sakaguchi, S., Barry, S. C., Huehn, J., Bonaguro, L., Ulas, T., & Beyer, M. (2023). Identification of the novel FOXP3-dependent T(reg) cell transcription factor MEOX1 by high-dimensional analysis of human CD4(+) T cells. Front Immunol, 14, 1107397. https://doi.org/10.3389/fimmu.2023.1107397 [Open Access]

Domingos, C., Müller, F. E., Passlick, S., Wachten, D., Ponimaskin, E., Schwarz, M. K., Schoch, S., Zeug, A., & Henneberger, C. (2023). Induced Remodelling of Astrocytes In Vitro and In Vivo by Manipulation of Astrocytic RhoA Activity. Cells, 12(2), 331. https://www.mdpi.com/2073-4409/12/2/331 [Open Access]

Nikolka, F., Karagöz, M. S., Nassef, M. Z., Hiller, K., Steinert, M., & Cordes, T. (2023). The Virulence Factor Macrophage Infectivity Potentiator (Mip) Influences Branched-Chain Amino Acid Metabolism and Pathogenicity of Legionella pneumophila. Metabolites, 13(7), 834. https://www.mdpi.com/2218-1989/13/7/834 [Open Access]

Wang, B., Wöhler, A., Greven, J., Salzmann, R. J. S., Keller, C. M., Tertel, T., Zhao, Q., Mert, Ü., Horst, K., Lupu, L., Huber-Lang, M., van Griensven, M., Mollnes, T. E., Schaaf, S., Schwab, R., Strassburg, C. P., Schmidt-Wolf, I. G. H., Giebel, B., Hildebrand, F., Lukacs-Kornek, V., Willms, A. G., & Kornek, M. T. (2023). Liquid Biopsy in Organ Damage: small extracellular vesicle chip-based assessment of polytrauma. Front Immunol, 14, 1279496. https://doi.org/10.3389/fimmu.2023.1279496 [Open Access]

Jenster, L.M., Lange, K.E., Normann, S., vom Hemdt, A., Wuerth, J.D., Schiffelers, L.D.J., Tesfamariam, Y.M., Gohr, F.N., Klein, L., Kaltheuner, I.H., Ebner, S., Lapp, D.J., Mayer, J., Moecking, J., Ploegh, H.L., Latz, E., Meissner, F., Geyer, M., Kummerer, B.M., and Schmidt, F.I. (2023). P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection. J Exp Med, 220. https://doi.org/10.1084/jem.20220837 [Open Access]

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Xu, Q., Vogt, A., Frechen, F., Yi, C., Küçükerden, M., Ngum, N., Sitjà-Roqueta, L., Greiner, A., Parri, R., Masana, M., Wenger, N., Wachten, D., & Möglich, A. (2023). Engineering Bacteriophytochrome-coupled Photoactivated Adenylyl Cyclases for Enhanced Optogenetic cAMP Modulation. Journal of Molecular Biology, 168257. https://doi.org/10.1016/j.jmb.2023.168257

Carraro, C., Bonaguro, L., Srinivasa, R., van Uelft, M., Isakzai, V., Schulte-Schrepping, J., Gambhir, P., Elmzzahi, T., Montgomery, J. V., Hayer, H., Li, Y., Theis, H., Kraut, M., Mahbubani, K. T., Aschenbrenner, A. C., König, I., Fava, E., Fried, H.-U., De Domenico, E., Beyer, M., Saglam, A., & Schultze, J. L. (2023). Chromatin accessibility profiling of targeted cell populations with laser capture microdissection coupled to ATAC-seq. Cell Reports Methods, 3(10), 100598. https://doi.org/10.1016/j.crmeth.2023.100598 [Open Access]

Prochnicki, T., Vasconcelos, M. B., Robinson, K. S., Mangan, M. S. J., De Graaf, D., Shkarina, K., Lovotti, M., Standke, L., Kaiser, R., Stahl, R., Duthie, F. G., Rothe, M., Antonova, K., Jenster, L. M., Lau, Z. H., Rosing, S., Mirza, N., Gottschild, C., Wachten, D., Gunther, C., Kufer, T. A., Schmidt, F. I., Zhong, F. L., & Latz, E. (2023). Mitochondrial damage activates the NLRP10 inflammasome. Nat Immunol, 24(4), 595-603. https://doi.org/10.1038/s41590-023-01451-y [Open Access]

Wunderling, K., Zurkovic, J., Zink, F., Kuerschner, L., & Thiele, C. (2023). Triglyceride cycling enables modification of stored fatty acids. Nat Metab, 5(4), 699-709. https://doi.org/10.1038/s42255-023-00769-z [Open Access]

Yuzeir, A., Bejarano, D. A., Grein, S., Hasenauer, J., Schlitzer, A., & Yu, J. (2023). IntestLine: a shiny-based application to map the rolled intestinal tissue onto a line. Bioinformatics, 39(4). https://doi.org/10.1093/bioinformatics/btad140 [Open Access]

Nickenig, M., Mangan, M. S. J., Lee, H. E., Symeonidis, K., Henne, A., Kaiser, R., Geißmar, E., Garritsen, H., Abdullah, Z., Hiller, K., Latz, E., & Lauterbach, M. A. (2023). Cutting Edge: STING Induces ACLY Activation and Metabolic Adaptations in Human Macrophages through TBK1. J Immunol. https://doi.org/10.4049/jimmunol.2200835

Lakrisenko, P., Stapor, P., Grein, S., Paszkowski, L., Pathirana, D., Frohlich, F., Lines, G. T., Weindl, D., & Hasenauer, J. (2023). Efficient computation of adjoint sensitivities at steady-state in ODE models of biochemical reaction networks. PLoS Comput Biol, 19(1), e1010783. https://doi.org/10.1371/journal.pcbi.1010783 [Open Access]

Hackstein, C. P., Spitzer, J., Symeonidis, K., Horvatic, H., Bedke, T., Steglich, B., Klein, S., Assmus, L. M., Odainic, A., Szlapa, J., Kessler, N., Beyer, M., Schmithausen, R., Latz, E., Flavell, R. A., Garbi, N., Kurts, C., Kummerer, B. M., Trebicka, J., Roers, A., Huber, S., Schmidt, S. V., Knolle, P. A., & Abdullah, Z. (2023). Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury. J Hepatol, 79(1), 150-166. https://doi.org/10.1016/j.jhep.2023.02.026 [Open Access]

Fox, F. A. U., Liu, D., Breteler, M. M. B., & Aziz, N. A. (2023). Physical activity is associated with slower epigenetic ageing-Findings from the Rhineland study. Aging Cell, 22(6), e13828. https://doi.org/10.1111/acel.13828 [Open Access]

Liu, D., Aziz, N. A., Pehlivan, G., & Breteler, M. M. B. (2023). Cardiovascular correlates of epigenetic aging across the adult lifespan: a population-based study. Geroscience, 45(3), 1605-1618. https://doi.org/10.1007/s11357-022-00714-0 [Open Access]

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Mass, E., Nimmerjahn, F., Kierdorf, K., & Schlitzer, A. (2023). Tissue-specific macrophages: how they develop and choreograph tissue biology. Nat Rev Immunol, 23(9), 563-579. https://doi.org/10.1038/s41577-023-00848-y [Open Access]

Swietlik, J. J., Barthel, S., Falcomata, C., Fink, D., Sinha, A., Cheng, J., Ebner, S., Landgraf, P., Dieterich, D. C., Daub, H., Saur, D., & Meissner, F. (2023). Cell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation. Nat Commun, 14(1), 2642. https://doi.org/10.1038/s41467-023-38171-8 [Open Access]

Alamoudi, E., Schälte, Y., Müller, R., Starruß, J., Bundgaard, N., Graw, F., Brusch, L., & Hasenauer, J. (2023). FitMultiCell: simulating and parameterizing computational models of multi-scale and multi-cellular processes. Bioinformatics, 39(11). https://doi.org/10.1093/bioinformatics/btad674 [Open Access]

Schälte, Y., Fröhlich, F., Jost, P. J., Vanhoefer, J., Pathirana, D., Stapor, P., Lakrisenko, P., Wang, D., Raimúndez, E., Merkt, S., Schmiester, L., Städter, P., Grein, S., Dudkin, E., Doresic, D., Weindl, D., & Hasenauer, J. (2023). pyPESTO: a modular and scalable tool for parameter estimation for dynamic models. Bioinformatics, 39(11). https://doi.org/10.1093/bioinformatics/btad711 [Open Access]

Gnirck, A. C., Philipp, M. S., Waterhölter, A., Wunderlich, M., Shaikh, N., Adamiak, V., Henneken, L., Kautz, T., Xiong, T., Klaus, D., Tomczyk, P., Al-Bahra, M. M., Menche, D., Walkenhorst, M., Lantz, O., Willing, A., Friese, M. A., Huber, T. B., Krebs, C. F., Panzer, U., Kurts, C., & Turner, J. E. (2023). Mucosal-associated invariant T cells contribute to suppression of inflammatory myeloid cells in immune-mediated kidney disease. Nat Commun, 14(1), 7372. https://doi.org/10.1038/s41467-023-43269-0 [Open Access]

Heuser-Loy, C., Baumgart, A. K., Hackstein, C. P., Courrèges, C. J. F., Philipp, M. S., Thaiss, C. A., Holland, T., Evaristo, C., Garbi, N., & Kurts, C. (2023). Conditional NKT Cell Depletion in Mice Reveals a Negative Feedback Loop That Regulates CTL Cross-Priming. J Immunol. https://doi.org/10.4049/jimmunol.2300662

Liu, D., Aziz, N. A., Landstra, E. N., & Breteler, M. M. B. (2023). The lipidomic correlates of epigenetic aging across the adult lifespan: A population-based study. Aging Cell, 22(9), e13934. https://doi.org/10.1111/acel.13934 [Open Access]

Yin, J., Mei, Q., Prinz, M., Abdullah, Z., Panzer, U., Li, J., von Vietinghoff, S., & Kurts, C. (2023). Fate mapping reveals compartment-specific clonal expansion of mononuclear phagocytes during kidney disease. Kidney Int, 104(3), 605-610. https://doi.org/10.1016/j.kint.2023.04.031 [Open Access]

Steiner, S., Fehrer, A., Hoheisel, F., Schoening, S., Aschenbrenner, A., Babel, N., Bellmann-Strobl, J., Finke, C., Fluge, Ø., Froehlich, L., Goebel, A., Grande, B., Haas, J. P., Hohberger, B., Jason, L. A., Komaroff, A. L., Lacerda, E., Liebl, M., Maier, A., Mella, O., Nacul, L., Paul, F., Prusty, B. K., Puta, C., Riemekasten, G., Ries, W., Rowe, P. C., Sawitzki, B., Shoenfeld, Y., Schultze, J. L., Seifert, M., Sepúlveda, N., Sotzny, F., Stein, E., Stingl, M., Ufer, F., Veauthier, C., Westermeier, F., Wirth, K., Wolfarth, B., Zalewski, P., Behrends, U., & Scheibenbogen, C. (2023). Understanding, diagnosing, and treating Myalgic encephalomyelitis/chronic fatigue syndrome - State of the art: Report of the 2nd international meeting at the Charité Fatigue Center. Autoimmun Rev, 22(11), 103452. https://doi.org/10.1016/j.autrev.2023.103452 [Open Acces]

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2022

Hansen, J. N., Kaiser, F., Leyendecker, P., Stüven, B., Krause, J.-H., Derakhshandeh, F., Irfan, J., Sroka, T. J., Preval, K. M., Desai, P. B., Kraut, M., Theis, H., Drews, A.-D., De-Domenico, E., Händler, K., Pazour, G. J., Henderson, D. J. P., Mick, D. U., & Wachten, D. (2022). A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation. EMBO reports, 23(8), e54315. https://doi.org/10.15252/embr.202154315 [Open Access]

Henne, A., Vigh, A., Martens, A., Nonnenmacher, Y., Ohm, M., Hosseini, S., More, T. H., Lauterbach, M. A., Garritsen, H., Korte, M., He, W., & Hiller, K. (2022). SiMeEx, a simplified method for metabolite extraction of adherent mammalian cells. Front Mol Biosci, 9, 1084060. https://doi.org/10.3389/fmolb.2022.1084060 [Open Access]

More, T. H., Mozafari, B., Märtens, A., Herr, C., Lepper, P. M., Danziger, G., Volk, T., Hoersch, S., Krawczyk, M., Guenther, K., Hiller, K., & Bals, R. (2022). Plasma Metabolome Alterations Discriminate between COVID-19 and Non-COVID-19 Pneumonia. Metabolites, 12(11), 1058. https://www.mdpi.com/2218-1989/12/11/1058 [Open Access]

Malik, M. N. H., Waqas, S. F.-u.-H., Zeitvogel, J., Cheng, J., Geffers, R., Gouda, Z. A.-E., Elsaman, A. M., Radwan, A. R., Schefzyk, M., Braubach, P., Auber, B., Olmer, R., Müsken, M., Roesner, L. M., Gerold, G., Schuchardt, S., Merkert, S., Martin, U., Meissner, F., Werfel, T., & Pessler, F. (2022). Congenital deficiency reveals critical role of ISG15 in skin homeostasis. The Journal of Clinical Investigation, 132(3). https://doi.org/10.1172/JCI141573 [Open Access]

Georg, P., Astaburuaga-García, R., Bonaguro, L., ..., Schultze, J. L., Aschenbrenner, A. C., Thibeault, C., Kurth, F., Sander, L. E., Blüthgen, N., & Sawitzki, B. (2022). Complement activation induces excessive T cell cytotoxicity in severe COVID-19. Cell, 185(3), 493-512.e425. https://doi.org/10.1016/j.cell.2021.12.040 [Open Access]

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2021

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