Maternal obesity impacts offspring health by increasing the risk of allergies, metabolic disorders, and neurological diseases. Our research has shown that maternal obesity programs liver macrophages, disrupting their functions and contributing to fatty liver disease. Building on this, we hypothesize that maternal-derived factors also affect brain-resident macrophages, such as microglia, during critical developmental stages. In this project, we aim to study how maternal obesity influences brain architecture and macrophage function, leading to potential developmental and behavioral consequences. Our findings will provide insights into the intergenerational effects of obesity and inform potential intervention strategies.

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