Macrophages play a critical role in immune defense and inflammatory regulation, but their functions extend far beyond these traditional roles. Recent research shows that elevated sodium levels disrupt key macrophage functions like migration, phagocytosis, and efferocytosis. This project investigates how high-salt diet affects macrophages in the gut-liver axis, where dietary signals constantly influence immunity. We aim to uncover how sodium intake alters macrophage functions, metabolic reprogramming, and tissue responses, contributing to metaflammation. Using in vivo models and macrophage culture systems, we will explore the molecular pathways involved, providing insights into the impact of sodium on health and disease.

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